Year: 2024
Type: article
Abstract: Endocannabinoid (eCB)-mediated suppression of inhibitory synapses has been hypothesized, but this has not yet been demonstrated to occur in vivo because of the difficulty in tracking eCB dynamics and synaptic plasticity during behavior. In mice navigating a linear track, we observed location-specific eCB signaling in hippocampal CA1 place cells, and this was detected both in the postsynaptic membrane and the presynaptic inhibitory axons. All-optical in vivo investigation of synaptic responses revealed that postsynaptic depolarization was followed by a suppression of inhibitory synaptic potentials. Furthermore, interneuron-specific cannabinoid receptor deletion altered place cell tuning. Therefore, rapid, postsynaptic, activity-dependent eCB signaling modulates inhibitory synapses on a timescale of seconds during behavior.
Source: Science
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, Robert and Janice McNair Foundation, National Institutes of Health, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Probing synaptic and circuit mechanisms of hippocampal plasticity with all-optical electrophysiology, Dissecting hypothalamic pathways for seizure control, Local Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the Hippocampus, G2971767340, Cannabinoid control of epilepsy, Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center, Perisomatic inhibition in epilepsy, Dissecting Hypothalamic Pathways for Seizure Control, Activity-dependent endocannabinoid control in epilepsy, Brain-spanning and scale-crossing circuitry mediating drive function and dysfunction
OpenAlex ID: W4392282828