Work

Nascent shifts in renal cellular metabolism, structure, and function due to chronic empagliflozin in prediabetic mice

Year: 2024

Type: article

Abstract: Renal protection afforded by sodium glucose transporter, type 2 inhibitors (SGLT2i), e.g., empagliflozin (EMPA) involves complex intertwined mechanisms. Using a novel mouse model of obesity with insulin resistance, the TallyHo/Jng (TH) mouse on a high-milk-fat diet (HMFD), we found subtle changes in metabolism including altered regulation of sodium transporters that line the renal tubule. New potential epigenetic determinants of metabolic changes relating to FOXO and cancer signaling pathways were elucidated from an altered urine exosomal microRNA signature.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00446.2023

Authors: Blythe D. Shepard, Jennifer Chau, Ryan Kurtz, Avi Z. Rosenberg, Pinaki Sarder, Samuel P. Border, Brandon Ginley, Olga Rodriguez, Chris Albanese, Grace Knoer, Aarenee Greene, Aline M. A. De Souza, Suman Ranjit, Moshe Levi, Carolyn M. Ecelbarger

Institutions: Georgetown University, Johns Hopkins University, University of Florida, University at Buffalo, State University of New York, Georgetown Lombardi Comprehensive Cancer Center

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, J. Willard and Alice S. Marriott Foundation, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences

Awards: G1773452051, G2253811589, G317133543, G7169432376, The role of renin angiotensin system in severe caloric restriction pathophysiology, Preclinical Imaging - Bruker 70/30USR BioSpec Magnet, Georgetown University Lombardi Comprehensive Cancer Center Support Grant, Role of Estrogen Related Receptors in Age Related Kidney Disease

OpenAlex ID: W4392370673

FWCI: 1.617

Cites: 94

Cited by: 6

Related to: 10