Year: 2024
Type: article
Abstract: Experts from 17 consortia are collaborating on the Human Reference Atlas (HRA) which aims to map the human body at single cell resolution. To bridge across scales—from the meter size human body to the micrometer size single-cell level—organ experts are constructing anatomical structures, cell types plus biomarkers (ASCT+B) tables, and associated spatial reference objects. The 3rd HRA (v1.2) release features 26 organ-specific ASCT+B tables that cite 456 scholarly papers and are linked to 61 spatial reference objects and Organ Mapping Antibody Panels (OMAPs); it is authored by more than 120 experts. This paper presents the first analyses and visualizations showcasing what data and scholarly evidence exist for which organs and how experts relate to the organs covered in the HRA. To identify potential HRA authors and reviewers, we queried the Web of Science database for authors who work on the 33 organs targeted for the next HRA release (v1.3). To provide scientific evidence for the HRA, we identified 620 high-quality, single-cell experimental data sets for 58 organs published in 561 unique papers. The results presented are critical for understanding and communicating the quality of the HRA, planning for future tissue data collection, and inviting leading experts to contribute to the evolving atlas.
Source: Quantitative Science Studies
DOI: 10.1162/qss_a_00299
Authors: Yongxin Kong, Vicky Amar Daiya, Katy Börner
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $800
Funders: Institute of Museum and Library Services, Microsoft Research, Purdue University, University of Pennsylvania, Ohio State University, University of Minnesota, Michigan State University, Pennsylvania State University, China Scholarship Council, National Institutes of Health, College of Engineering, Michigan State University, NIH Office of the Director, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Common Fund
Awards: 3D Multiscale Biomolecular Human Reference Atlas Construction, Visualization and Usage [4 of 5], Central Hub for Kidney Precision Medicine, National Leadership Grants - Libraries — Indiana University (FY2018), G3718867181, G5496694919, The Human Body Atlas: High-Resolution, Functional Mapping of Voxel, Vector, and Meta Datasets, G8857852000, Cellular Senescence Network (SenNet) Consortium Organization and Data Coordinating Center (CODCC)
OpenAlex ID: W4392454521