Year: 2024
Type: article
Abstract: Organoiodine compounds belong to a very important class of functional molecules and their synthesis research is of great significance.Given the advantages of N-iodosuccinimide (NIS) with high reactivity, cheap and easy to get and environmental friendliness, it has always been the preferred iodine reagent for iodization, and in recent years, the preparation of organic iodine compounds by iodization reaction with NIS has made great progress, which has received considerable interest.To this end, the research progress is summarized, including the C-H iodization of NIS and aromatics/terminal alkynes, iodine difunctionalization between NIS and unsaturated compounds with nucleophiles, and cascade iodocyclization between NIS and unsaturated compounds.Keywords iodization; N-iodosuccinimide; organoiodine compounds 有机碘化合物是一类非常重要的功能性分子, 它们 不仅作为关键结构存在于众多天然产物分子中 [1] , 还是 非常重要的有机合成中间体, 广泛应用于有机金属试剂 制备、自由基中间体生成、亲核取代反应以及交叉偶联 反应等领域 [2][3] , 已成为全合成、药物化学以及材料科学 的重要构建模块.因此发展有机碘化合物的合成方法在 有机合成中具有非常重要的意义.近年来, 随着合成化学家对有机碘化合物制备方法 的探索, 涌现出了很多高效的碘试剂, 使得碘化反应取 得了长足的发展.其中, N-碘代丁二酰亚胺(NIS)因具有 反应活性高、 廉价易得和环境友好等优点, 备受关注 [4][5][6] .NIS 主要参与以下三类碘化反应: (1) NIS 与芳烃/醛/酮/ 末端炔烃的 C-H 碘化反应, 制备碘代芳烃、α-碘代羰 基化合物以及 1-碘炔类化合物;
Authors: Tongyang Cao, Wei Li, Lijing Wang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G3151394369, G6603304495
OpenAlex ID: W4392461716