Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective The objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood. Methods In a prospective birth cohort of Dominican and African American children from New York City, New York (1998–2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance at age 5, 7, 9, and 11 years. We used linear mixed‐effects models to assess associations of mtDNAcn tertiles in cord blood with child BMI, BMI z scores, fat mass index, and body fat percentage. Latent class growth models and interactions between mtDNAcn and child age or child age2 were used to assess associations between age and adiposity trajectories. Results BMI was, on average, 1.5 kg/m2 higher (95% CI: 0.58, 2.5) in individuals with mtDNAcn in the low‐ compared with the middle‐mtDNAcn tertile. Results were similar for BMI z score, fat mass index, and body fat percentage. Moreover, children in the low‐mtDNAcn group had increased odds of being in an “increasing” or “high‐stable” adiposity class. Conclusions Lower mtDNAcn at birth may predict greater childhood adiposity, highlighting the potential key role of perinatal mitochondrial function in adiposity during development.
Source: Obesity
DOI: 10.1002/oby.24005
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Black carbon exposure, DNA methylation, airway inflammation in pediatric asthma, Pre- and Postnatal PBDE Exposure, Thyroid Hormones, and Neurodevelopment, Prenatal Exposures to Flame-Retardants: Mitochondrial Signatures and Childhood Obesity, Center for Environmental Health in Northern Manhattan
OpenAlex ID: W4392592791