Work

Higher fluid and lower caloric intakes: associated risk of severe bronchopulmonary dysplasia in ELBW infants

Year: 2024

Type: article

Abstract: Objective To examine nutritional intake profiles and growth trajectories of extremely low birth weight (ELBW) infants who develop severe bronchopulmonary dysplasia (BPD). Study Design Case-control study using multiple logistic regression analysis with generalized estimating equations (GEE) to adjust for matching. Results Cumulative and mean fluid intakes were higher (p=0.003) and caloric intakes lower (p<.0001)through week two in infants who developed severe BPD (n=120) versus those without severe BPD (n=104). Mean caloric intake through week 12 was lower in infants who developed severe BPD (102±10.1 vs. 107±8.5 kcal/kg/day, p<0.0001). In logistic regression models, lower mean caloric intake through week 12 was associated with increased risk of developing severe BPD. Linear growth reduced the odds of BPD by ~30% for each Z-score point. Conclusions Higher fluid and lower total caloric intakes and reductions in linear growth were independently associated with an increased risk of developing severe BPD in ELBW infants.

Source: Journal of Perinatology

DOI: 10.1038/s41372-024-01928-0

Authors: Danielle Kolitz, Lynn Przystac, Richard Tucker, William Oh, Barbara S. Stonestreet

Institutions: Brown University, Women & Infants Hospital of Rhode Island

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: green

OpenAlex ID: W4392596447