P869: Building an equitable network to study genetic risk of severe acute malnutrition in multiple African populations
Year: 2024
Type: article
Abstract: The lack of diversity among human genetic studies has been well-documented in recent years, leading to multiple calls for increased representation of individuals from diverse ancestral groups. This ‘diversity gap’ is evident amongst reference databases derived from large-scale sequencing efforts, which are overwhelmingly populated by individuals of European ancestry. In fact, African populations represent <2% of all GWAS studies. Lack of representation leads to ambiguous genetic testing results and fails to capture unique admixture patterns and novel variants.
Source: Genetics in Medicine Open
Institutions: National Human Genome Research Institute, Kenya Medical Research Institute, University of Oxford, KEMRI-Wellcome Trust Research Programme, Queen Mary University of London, Tropical Gastroenterology & Nutrition group, Zvitambo Institute for Maternal and Child Health Research, Mulago Hospital, Botswana-Baylor Children's Clinical Center of Excellence, Haydom Lutheran Hospital, Baylor College of Medicine
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,200
OpenAlex ID: W4392606515