Work

P112: The expression profile of SLCO genes in hepatocellular carcinoma and their association with clinical outcomes

Year: 2024

Type: article

Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy that occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Organic anion transporter polypeptides (OATPs), encoded by SLCO genes, are one of the most important SLC subfamilies that involve in the cellular uptake of drug and endobiotic. OATP1B1 (SLCO1B1 gene), OATP1B3 (SLCO1B3 gene), OATP2B1 (SLCO2B1 gene) are hepatic uptake transporters highly expressed in the liver. We aimed to systematically analyze SLCO1B1, SLCO1B3 and SLCO2B1 expression and their prognostic role in HCC using various open databases.

Source: Genetics in Medicine Open

DOI: 10.1016/j.gimo.2024.100993

Author: Hubert Chen

Institution: Vanderbilt University

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,200