Work

Targeting TRP channels for pain relief: A review of current evidence from bench to bedside

Year: 2024

Type: review

Abstract: Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review discusses the role of TRP channels in human pain conditions.

Source: Current Opinion in Pharmacology

DOI: 10.1016/j.coph.2024.102447

Authors: Ari-Pekka Koivisto, Thomas Voets, Michael J. Iadarola, Arpad Szallasi

Institutions: VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, National Institutes of Health, National Institutes of Health Clinical Center, Semmelweis University

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,100