Impact of hyperhomocysteinemiaon carotid intima-media thickness in type 2 diabetes mellituswith or without hypertension: a retrospective observational study
Year: 2024
Type: preprint
Study design: Observational Study
Abstract: Background: The influence of hyperhomocysteinemia on carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM) and its interplay with hypertension remains uncertain. This study aimed to investigate the impact of hyperhomocysteinemia on CIMT in patients with T2DM, both with and without coexisting hypertension. Methods: This retrospective observational study was conducted at Shanghai Jiading District Central Hospital, enrolling patients with type 2 diabetes mellitus (T2DM) between January 2019 and December 2020. Data on serum homocysteine levels and carotid intima-media thickness (CIMT) were collected. Multivariable logistic regression analysis was employed to investigate the potential risk factors associated with CIMT in the entire cohort of T2DM patients and within specific hypertension subgroups. Results: The study sample comprised 423 patients diagnosed with T2DM, with a mean age of 59.99±14.59 years, including 258 males (60.99%), 258 hypertension patients (60.99%). Multivariable logistic regression analysis revealed a significant association between hyperhomocysteinemia and carotid intima-media thickness (CIMT) in all T2DM patients (odds ratio [OR]=2.942, 95% confidence interval [CI]: 1.356-6.386, P=0.006) and among patients with coexisting hypertension (OR=2.840, 95%CI: 1.153-6.999, P=0.040). However, no significant association was observed between hyperhomocysteinemia and CIMT in patients without hypertension (OR=1.123, 95%CI: 0.329-3.383, P=0.194). Conclusion: The findings highlight hyperhomocysteinemia as an independent risk factor for CIMT thickening in patients with T2DM, particularly among those with concomitant hypertension. These results underscore the importance of managing hyperhomocysteinemia in T2DM patients, particularly those with hypertension, to mitigate the risk of CIMT thickening and subsequent cardiovascular events.
Source: Research Square
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4392650794