Work

Modification of Protein Micelles by Limited Hydrolysis of Peptide Bonds: A Model of the Sequential Degradation of β-Casein Micelles

Year: 2024

Type: article

Abstract: A model for the degradation of β-casein micelles with the limited hydrolysis of trypsin-specific peptide bonds was proposed. A sequential mechanism of the degradation of micelles and assembly of peptide nanoparticles from the fragments of a β-casein polypeptide chain was considered. The degradation kinetics was studied by numerical modeling, taking into account the formation of intermediate components of different sizes and peptide nanoparticles, which are more difficult to hydrolyze with trypsin. The simulation results are consistent with the experimental data previously obtained by atomic force microscopy, FTIR spectroscopy, and light scattering.

Source: INEOS OPEN

DOI: 10.32931/io2313a

Authors: A. V. Golovanov, G. Güler, M. M. Vorob'ev

Institutions: Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds, Izmir Institute of Technology

Language: English

Topic: Proteins in Food Systems

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: hybrid

Funders: Russian Foundation for Basic Research, Ministry of Science and Higher Education of the Russian Federation

Award: G7948401880