Work

Early and rapid development of bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation

Year: 2024

Type: article

Abstract: Bronchiolitis obliterans (BO) is a form of graft-versus-host disease (GVHD) in the lung and manifests as moderate to severe airflow obstruction after hematopoietic stem cell transplantation (HCT). New-onset airflow obstruction on spirometry is considered diagnostic of bronchiolitis obliterans syndrome (BOS). BOS affects about 5% of all HCT recipients. In general, BO is thought of as a late complication of HCT, usually occurring after day 100 post-transplantation. However, the onset of airflow obstruction can be rapid and is most often irreversible even with treatment. We describe a patient who rapidly developed severe airflow obstruction less than one month after transplantation following the development of upper airway symptoms. Despite aggressive immunosuppression, the patient had no improvement in airflow obstruction. We hypothesize that early screening and treatment may help prevent BOS after HCT.

Source: Respiratory Medicine Case Reports

DOI: 10.1016/j.rmcr.2024.102001

Authors: Jacqueline S. Dickey, Burton F. Dickey, Amin M. Alousi, Richard E. Champlin, Ajay Sheshadri

Institutions: University of Utah, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200