Work

High-fat diet-induced AKT-palmitoylation in hepatocellular carcinoma: a breakthrough mechanistic investigation

Year: 2024

Type: article

Abstract: Primary liver cancer is the third leading cause of cancer-related mortality globally, accounting for over 700,000 deaths each year [1].In the last decade, the contribution of diet has been unraveled as a significant driver of hepatic oncogenesis [2].Specifically, diets high in fat have been associated with increased risk for the development of metabolic dysfunction-associated steatohepatitis (MASLD) and hepatocellular carcinoma (HCC) in many epidemiologic studies [3,4], and these findings have been recapitulated in various in vitro and in vivo models.Although the link between diet and tumorigenesis has been

Source: Gut

DOI: 10.1136/gutjnl-2023-331857

Authors: Claudia R Keating, Diego F Calvisi, Wei Qiu

Institutions: Loyola University Chicago, University of Regensburg

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Cancer Institute