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Diet composition impacts eQTL discovery across multiple tissues in baboons

Year: 2024

Type: article

Abstract: Understanding how genetic variation impacts gene expression is a major goal of genomics; however, only a fraction of disease-associated loci have been demonstrated to impact gene expression when cells are in an unperturbed “steady state.” In this issue of Cell Genomics , Lin et al. 1 1. Lin, W. ∙ Wall, J.D. ∙ Li, G. ... Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons Cell Genom. 2024; 4 , 100509 Full Text Full Text (PDF) Scopus (15) Google Scholar investigate how exposure to a particular cellular context (i.e., a high-cholesterol, high-fat diet) can enhance our ability to identify new regulatory variants through longitudinal sampling of three tissue types in the baboon.

Source: Cell Genomics

DOI: 10.1016/j.xgen.2024.100524

Authors: Rachel M. Petersen, Amanda J. Lea

Institution: Vanderbilt University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $8,900