Work

Toward a more holistic approach to the study of exposures and child outcomes

Year: 2024

Type: article

Abstract: Aim: The current work was designed to demonstrate the application of the exposome framework in examining associations between exposures and children's long-term neurodevelopmental and behavioral outcomes. Methods: Longitudinal data were collected from birth through age 6 from 402 preterm infants. Three statistical methods were utilized to demonstrate the exposome framework: exposome-wide association study, cumulative exposure and machine learning models, with and without epigenetic data. Results: Each statistical approach answered a distinct research question regarding the impact of exposures on longitudinal child outcomes. Findings highlight associations between exposures, epigenetics and executive function. Conclusion: Findings demonstrate how an exposome-based approach can be utilized to understand relationships between internal (e.g., DNA methylation) and external (e.g., prenatal risk) exposures and long-term developmental outcomes in preterm children.

Source: Epigenomics

DOI: 10.2217/epi-2023-0424

Authors: Barry M Lester, Marie Camerota, Todd M Everson, Coral L Shuster, Carmen J Marsit

Institutions: Brown University, Women & Infants Hospital of Rhode Island, Emory University

Language: English

Topic: Health, Environment, Cognitive Aging

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Mental Health, National Institute of Environmental Health Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development