Work

Advances in Skin-on-a-Chip Technologies for Dermatological Disease Modeling

Year: 2024

Type: review

Abstract: Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models. In this paper, we review current SoC technologies, highlighting their potential as an alternative to animal models for a deeper understanding of complex skin conditions.

Source: Journal of Investigative Dermatology

DOI: 10.1016/j.jid.2024.01.031

Authors: Seo Won Cho, Hamza Malick, Soo Jung Kim, Alessandro Grattoni

Institutions: Houston Methodist, Houston Methodist Research Institute, Texas A&M University, Baylor College of Medicine

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,400