FIGURE 5 from Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts
Year: 2024
Type: other
Abstract: Synergy between TAK-243 and mitotane. A, Top: The indicated ACC cell lines were treated with TAK-243 with or without mitotane for 72 hours. Bottom: CI values were calculated and plotted. B, Enhanced induction of apoptosis by the TAK-243 + mitotane combination was measured as caspase-3 cleavage. C, Enhanced UPR induction by the TAK-243 + mitotane combination. CU-ACC2 cells were treated with or without mitotane (40 µmol/L) for 24 hours before adding the indicated concentrations of TAK-243 for 4 hours. UPR proteins were evaluated by Western blotting.
Authors: Yasuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Anish Thomas, Nitin Roper, Diana Grace Varghese, Naoko Takebe, Xiaohu Zhang, Michele Ceribelli, David O. Holland, Erin Beck, Zina Itkin, Crystal McKnight, Kelli M. Wilson, Jameson Travers, Carleen Klumpp-Thomas, Craig J. Thomas, Chuong D. Hoang, Jonathan M. Hernandez, Jaydira Del Rivero, Yves Pommier
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4392952285