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Adrenal-PermissiveHSD3B1Genotype—An Invisible Stimulator of Prostate Cancer Mortality

Year: 2024
Type: article
Study design: Observational Study
Abstract: 3%-2.4%; P = .02). 4 The cumulative incidence of PCSM for men who developed metastatic prostate cancer was significantly elevated for those with homozygous adrenal-permissive inheritance (36.0%; 95% CI, 16.7%-50.8%)compared with men with homozygous adrenal-restrictive inheritance (18.5%; 95% CI, 12.0%-24.6%)and heterozygous inheritance (17.9%; 95% CI, 10.5%-24.7%;P = .01). 4 For men with nonmetastatic prostate cancer at diagnosis, the cumulative incidence was also significantly higher for men with adrenal-permissive homozygous inheritance (1.8%; 95% CI, 0.0%-3.5%)
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,000
OpenAlex ID: W4392986241
FWCI: 1.775
Cites: 7
Cited by: 7
Related to: 10