Work

Ferroptosis in organ fibrosis: From mechanisms to therapeutic medicines

Year: 2024

Type: article

Abstract: Fibrosis occurs in many organs, and its sustained progress can lead to organ destruction and malfunction. Although numerous studies on organ fibrosis have been carried out, its underlying mechanism is largely unknown, and no ideal treatment is currently available. Ferroptosis is an iron-dependent process of programmed cell death that is characterized by lipid peroxidation. In the past decade, a growing body of evidence demonstrated the association between ferroptosis and fibrotic diseases, while targeting ferroptosis may serve as a potential therapeutic strategy. This review highlights recent advances in the crosstalk between ferroptosis and organ fibrosis, and discusses ferroptosis-targeted therapeutic approaches against fibrosis that are currently being explored.

Source: Journal of Translational Internal Medicine

DOI: 10.2478/jtim-2023-0137

Authors: Weijing Lai, Bo Wang, Rongshuang Huang, Chuyue Zhang, Ping Fu, Liang Ma

Institutions: Sichuan University, West China Hospital of Sichuan University, First Affiliated Hospital of Chengdu Medical College

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,706