Work

Integrating the response to stressed mitochondria

Year: 2024

Type: article

Abstract: demonstrate that phospho-EIF2α (pEIF2α), the translation initiation factor that mediates the integrated stress response (ISR), is necessary and sufficient for the autophagic degradation of mitochondria following the addition of mitochondrial stressors.

Source: Molecular Cell

DOI: 10.1016/j.molcel.2024.02.026

Authors: Elliot Dine, Richard J. Youle

Institution: National Institute of Neurological Disorders and Stroke

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $9,350