Work

Mechanisms of coronary sinus reducer for treatment of myocardial ischemia: in silico study

Year: 2024

Type: article

Abstract: Emerging coronary venous retroperfusion treatments, particularly coronary sinus reducer (CSR) for refractory angina linked to myocardial ischemia, show promise; however, their mechanisms of action are not well understood. We find that CSR's effectiveness varies with the severity of coronary stenosis. In moderate stenosis, CSR improves tissue oxygenation by increasing capillary transit time, whereas in severe stenosis, it redistributes blood from nonischemic to ischemic regions and reduces capillary flow heterogeneity.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00910.2023

Authors: Haifeng Wang, Lei Fan, Jenny S. Choy, Ghassan S. Kassab, Lik Chuan Lee

Institutions: Michigan State University, Marquette University, Medical College of Wisconsin, California Medical Innovations Institute

Language: English

Topic: Coronary Interventions and Diagnostics

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute