Associations between phenotypes of childhood and adolescent obesity and incident hypertension in young adulthood
Year: 2024
Type: article
Study design: Observational Study
Abstract: Objectives We investigated whether empirically derived childhood obesity phenotypes were differentially associated with risk of hypertension in young adulthood, and whether these associations differed by sex. Methods Data came from 11,404 participants in the Growing Up Today Study, a prospective cohort study in the US established in 1996. We used a childhood obesity phenotype variable that was previously empirically derived using latent class analysis. The childhood obesity phenotypes included an early puberty phenotype (females only), a mothers with obesity phenotype, a high weight concerns phenotype, and a mixed phenotype. Participants without overweight or obesity in childhood or adolescence were the reference group. We then used logistic regression models with generalized estimating equations to examine associations of childhood obesity phenotypes with incident hypertension between ages 20–35 years. All analyses were stratified by sex. Results Among females, participants in all of the empirically derived childhood obesity phenotypes were more likely than their peers without childhood overweight/obesity to develop hypertension in young adulthood (early puberty subtype odds ratio (OR) = 2.52; 95% confidence interval (CI) = 1.75, 3.62; mothers with obesity (MO) subtype OR = 2.98; 95% CI = 1.93, 4.59; high weight concerns (WC) subtype OR = 2.33; 95% CI = 1.65, 3.28; mixed subtype OR = 1.66; 95% CI = 1.25, 2.20). Among males, the childhood obesity phenotypes were associated with a higher risk of developing hypertension, although males in the MO (OR = 2.65; 95% CI = 1.82, 3.87) and WC phenotypes (OR = 3.52; 95% CI = 2.38, 5.20) had a greater risk of developing hypertension than the mixed subtype (OR = 1.51; 95% CI = 1.23, 1.86) (p = 0.004). Conclusion Risk for incident hypertension in young adulthood varied by childhood obesity phenotypes, as well as by biological sex. If replicated, these results may suggest that increased surveillance of specific childhood obesity phenotypes might help in targeting those at highest risk for hypertension.
Source: International Journal of Obesity
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Brigham and Women's Hospital, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: The Development of Eating Disorders in Males and Females, Sexual Orientation and Obesity: Test of a Gendered Biopsychosocial Model, Empirical eating disorder classification and validation using prospective studies, Patient-oriented research in early life origins of CVD, Boston Nutrition Obesity Research Center, Impact of Violence on Obesity & Reproductive Axes in Youth, Substance Disorders, Substance Use Treatment, and Sexual Orientation in Youth, Phenotyping obesity using behavioral, psychological, physiological, familial, and genetic data, G9000029955, Disparities in Exposure and Health Effects of Multiple Environmental Stressors Across the Life Course, Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research, Physiology, Psychology, and Genetics of Obesity
OpenAlex ID: W4405421668