Exposure to 4,4′‐ DDE in visceral adipose tissue and weight loss in adolescents from the Teen‐LABS cohort
Year: 2024
Type: article
Abstract: OBJECTIVE: Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes. METHODS: We included 63 participants from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort. We assessed 4,4'-DDE in visceral adipose tissue at surgery and BMI and waist circumference at surgery and 0.5, 1, 3, and 5 years after. We conducted longitudinal analysis to estimate the interaction on weight loss between DDE and time since surgery. In vitro analysis quantified adipogenic differentiation in commercial human preadipocytes exposed to 4,4'-DDE via fluorescent staining and imaging. RESULTS: A dose-response relationship was observed, with the low-exposure group having a greater reduction in BMI during the first year compared to higher-exposure groups and showing smaller regains compared to higher-exposure groups after the first year. In vitro analysis of preadipocytes treated with 4,4'-DDE during adipogenic differentiation for 12 days showed a concentration-dependent increase in lipid accumulation. CONCLUSIONS: DDE could contribute to weight trajectory among adolescents undergoing bariatric surgery, potentially mediated via promoted adipogenesis in preadipocytes.
Source: Obesity
DOI: 10.1002/oby.24009
Authors: Bruna Rubbo, Zhenjiang Li, Phum Tachachartvanich, Brittney O. Baumert, Hongxu Wang, Shudi Pan, Sarah Rock, Justin R. Ryder, Todd Jenkins, Stephanie Sisley, Xiangping Lin, Scott Bartell, Thomas H. Inge, Stavra Xanthakos, Brooklynn McNeil, Anna R. Robuck, Michele A. La Merrill, Douglas I. Walker, David V. Conti, Rob McConnell, Sandrah P. Eckel, Lida Chatzi
Institutions: University of Southern California, Chulabhorn Research Institute, University of California, Davis, Northwestern University, Lurie Children's Hospital, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Baylor College of Medicine, Children's Nutrition Research Center at Baylor College of Medicine, Icahn School of Medicine at Mount Sinai, University of California, Irvine, Columbia University, Emory University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,740
Awards: G1339695942, Continuation of Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS), Biostatistics Research Center, G31452788, Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals
OpenAlex ID: W4393095100