Work

Design of Antigen-Specific Antibody CDRH3 Sequences Using AI and Germline-Based Templates

Year: 2024

Type: preprint

Abstract: Antibody-antigen specificity is engendered and refined through a number of complex B cell processes, including germline gene recombination and somatic hypermutation. Here, we present an AI-based technology for de novo generation of antigen-specific antibody CDRH3 sequences using germline-based templates, and validate this technology through the generation of antibodies against SARS-CoV-2. AI-based processes that mimic the outcome, but bypass the complexity of natural antibody generation, can be efficient and effective alternatives to traditional experimental approaches for antibody discovery.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2024.03.22.586241

Authors: Toma M. Marinov, Alexandra A. Abu-Shmais, Alexis K. Janke, Ivelin S. Georgiev

Institutions: Vanderbilt University Medical Center, Vanderbilt University

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Vanderbilt University, National Institutes of Health, National Institute of Allergy and Infectious Diseases