Abstract 1960 The N-terminal Per-Arnt-Sim (PAS) domain of hERG channels allosterically regulates channel closure and couples the voltage sensor to the pore gate
Year: 2024
Type: conference-abstract
Abstract: Human ether-á-go-go related gene (hERG) is a voltage-gated potassium channel that is critical for cardiac excitability. Within the KCNH channel hERG, interactions between the N-terminal Per-Arnt-Sim (PAS) of one subunit and the C-terminal Cyclic Nucleotide Binding Homology Domain (CNBHD) of a neighboring subunit has been implicated in the characteristic slow closing of the channel gate. Yet, how domains distal to the pore rearrange during gating to regulate channel the pore (and ion flux) is unclear.
Source: Journal of Biological Chemistry
Authors: Sara Codding, Matthew Trudeau
Institution: University of Maryland, Baltimore
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W4393138945