Year: 2024
Type: conference-abstract
Abstract: The modification of histone H3, particularly at the 27th lysine residue, plays a pivotal role in regulating gene expression. Methylation or acetylation of H3K27 significantly impacts the compaction of DNA around histones, thereby affecting gene accessibility to transcriptional machinery. Dysregulation or mutation of enzymes modulating H3K27 in pediatric cancer implies a link between these modifications and cancer development. Understanding these modifications on gene expression could lead to targeted therapies or specific diagnostic tools for pediatric tumors.
Source: Journal of Biological Chemistry
Authors: Bridget Mwaniki, Nina Connolly, Jamy Peng
Institutions: Rhodes College, University of Massachusetts Boston
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W4393138974