Work

211P Transcriptional and epigenetic landscape of neuroendocrine transformation during emergence of resistance to targeted therapies in EGFR mutant lung adenocarcinoma

Year: 2024

Type: article

Abstract: Histological transformation from lung adenocarcinoma (LUAD) to small cell carcinoma (SCLC) is a signature example of lineage plasticity (LP) and the primary mechanism of acquired resistance in up to 15% of EGFR-mutant LUADs. It is a dynamic process controlled by transcriptional and epigenetic dysregulation. We determine the transcriptional and epigenetic regulators of LP and their interplay with tumor microenvironment.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2024.102784

Author: T. Sen

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,730