Work

Abstract 1982 Targeting Sialic Acids with Streptococcal Adhesin Proteins

Year: 2024

Type: conference-abstract

Abstract: Glycans terminating with sialic acid (sialoglycans) are important for many biological functions and are ubiquitous in both bacterial and mammalian cells. When found on mammalian cell surfaces one function is to act as ligands for sialic-acid-binding immunoglobulin-like lectins which suppresses autoimmunity. Likely linked to the attenuation of the immune response, aberrant glycosylation has been linked to initial oncogenic transformation and promotes tumor cell metastasis. This could make sialoglycan detection on cell surfaces a way to distinguish cancer cells.

Source: Journal of Biological Chemistry

DOI: 10.1016/j.jbc.2024.106314

Authors: KeAndreya Morrison, Barbara Bensing, Hai Yu, Xi Chen, Paul Sullam, T. Iverson

Institution: Meharry Medical College

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800