Year: 2024
Type: conference-abstract
Abstract: Objective: Genome of cells is often challenged by insults from endogenous resources or environmental toxins, leading to different types of DNA damages including oxidized and methylated bases, Apurinic/apyrimidinic (AP) sites, DNA single-strand breaks (SSBs), and double-strand breaks (DSBs). Unrepaired AP sites, SSBs and DSBs impair DNA replication and transcription machineries, leading to genome instability and associated diseases such as cancer and neurodegenerative disorders. Cells have evolved various DNA repair and DNA damage response (DDR) pathways to mitigate various DNA damage for genome integrity maintenance.
Source: Journal of Biological Chemistry
Author: Shan Yan
Institution: University of North Carolina at Charlotte
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W4393167671