Neurophotonics beyond the surface: unmasking the brain’s complexity exploiting optical scattering
Year: 2024
Type: article
Abstract: The intricate nature of the brain necessitates the application of advanced probing techniques to comprehensively study and understand its working mechanisms. Neurophotonics offers minimally invasive methods to probe the brain using optics at cellular and even molecular levels. However, multiple challenges persist, especially concerning imaging depth, field of view, speed, and biocompatibility. A major hindrance to solving these challenges in optics is the scattering nature of the brain. This perspective highlights the potential of complex media optics, a specialized area of study focused on light propagation in materials with intricate heterogeneous optical properties, in advancing and improving neuronal readouts for structural imaging and optical recordings of neuronal activity. Key strategies include wavefront shaping techniques and computational imaging and sensing techniques that exploit scattering properties for enhanced performance. We discuss the potential merger of the two fields as well as potential challenges and perspectives toward longer term in vivo applications.
Source: Neurophotonics
Language: English
Subfield: Acoustics and Ultrasonics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,675
Awards: G120131529, In vivo Imaging of Neuroactivity in the Deep Forward Scattering Regime Using Speckle Identification and Demixing (SPID) Microscopy, Memory in living systems: an integrated approach, Bringing laser focus to voltage imaging: Enhanced indicators and advanced scanning methods for two-photon recording of dense networks in vivo, G1449229046, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE, G1742243815, G196500007, G2031799572, G2423307659, Cortical computation of expectancy to highly predictable tactile stimuli, G4344760965, G4573130097, G4866930200, G4950536974, Acousto-optic Light Patterning for the Imaging of Neurons and Stimulation, G6200768123, G6803667113, ComputatIonal coherent Raman far-fIeld nanoscopy, G6987149703, G7240651115, G746376862, Institut Q-LIFE, G782245399, Dynamic adaptive microscopy for label-free multi-parametric imaging in biology and medicine, G8858395165
OpenAlex ID: W4394742098