FIGURE 5 from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment
Year: 2024
Type: other
Abstract: Comparison of pulmonary healthy and diseased endothelial cells and fibroblasts characterize their distribution and tumor-specific interplays with START. A, Split t-SNE plot distribution of the four endothelial clusters identified in healthy lungs (left), Vehicle- (middle), and Unesbulin-treated tumors (right). Each color represents a defined transcriptional cluster. B, Histograms representing the percentage contribution of endothelial clusters per sample (healthy lungs, Vehicle- and Unesbulin-treated tumors). C, Venn diagram showing common and unique GO categories/ biological processes enriched in endothelial cells from each sample (healthy lungs, Vehicle- and Unesbulin-treated tumors). D, Heat map showing the predicted interactions between endothelial cells and START in Vehicle- (red) and Unesbulin-treated tumors (light blue). E, Heat map showing the predicted interactions between START and endothelial in Vehicle- (red) and Unesbulin-treated tumors (light blue). F, Sankey plot of the protumorigenic phenotypes promoted on START by endothelial-secreted ligands (left) and on endothelial cells by START-secreted ligands (right). G, Split t-SNE plot distribution of the fibroblast clusters identified in healthy lungs (left), Vehicle- (middle), and Unesbulin-treated tumors (right). Each color represents a defined transcriptional cluster. H, Histograms representing the percentage contribution of fibroblast clusters per sample (healthy lungs, Vehicle-, and Unesbulin-treated tumors). I, Venn diagram showing common and unique GO categories/biological processes enriched in fibroblasts from each sample (healthy lungs, Vehicle- and Unesbulin-treated tumors). J, Heat map showing the predicted interactions between START and fibroblasts in Vehicle- (red) and Unesbulin-treated tumors (light blue). K, Heat map showing the predicted interactions between fibroblasts and START in Vehicle- (red) and Unesbulin-treated tumors (light blue). L, Sankey plot of the protumorigenic phenotypes promoted on START by fibroblast-secreted ligands (left) and on fibroblasts by START-secreted ligands (right).
Authors: Giorgia Maroni, Indira Krishnan, Roberta Alfieri, Valerie A. Maymi, Nicole Pandell, Eva Csizmadia, Junyan Zhang, Marla Weetall, Art Branstrom, Giulia Braccini, Eva Cabrera San Millán, Barbara Storti, Ranieri Bizzarri, Olivier Kocher, Daniela S. Daniela Sanchez Bassères, Robert S. Welner, Maria Cristina Magli, Ivan Merelli, John G. Clohessy, Azhar Ali, Daniel G. Tenen, Elena Levantini
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4393181684