Structure-based Design of CBP/EP300 Degraders: When Coopera-tivity Overcomes Affinity
Work
Year: 2024
Type: preprint
Abstract: Here we present the development of dCE-2, a structurally novel PROTAC targeting the CREB-binding protein (CBP) and E1A-associated protein (EP300) – two homologous multidomain enzymes crucial for enhan... more
Authors Iván Cheng‐Sánchez, Katherine Gosselé, Leonardo Palaferri, Eleen Laul, Gionata Riccabella +5 more
Institution University of Zurich
Cites: 55
Cited by: 2
Related to: 10
Citation percentile (by year/subfield): 92.24
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Sustainable Development Goal Clean water and sanitation
Open Access status: green