Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes
Year: 2024
Type: article
Study design: Observational Study
Abstract: Cardiorespiratory fitness and mitochondrial oxidative capacity are associated with reduced walking speed in older adults, but their impact on walking speed in older adults with diabetes has not been clearly defined. We examined differences in cardiorespiratory fitness and skeletal muscle mitochondrial oxidative capacity between older adults with and without diabetes, as well as determined their relative contribution to slower walking speed in older adults with diabetes. Participants with diabetes (n = 159) had lower cardiorespiratory fitness and mitochondrial respiration in permeabilized fiber bundles compared with those without diabetes (n = 717), following adjustments for covariates including BMI, chronic comorbid health conditions, and physical activity. Four-meter and 400-m walking speeds were slower in those with diabetes. Mitochondrial oxidative capacity alone or combined with cardiorespiratory fitness mediated ∼20-70% of the difference in walking speed between older adults with and without diabetes. Additional adjustments for BMI and comorbidities further explained the group differences in walking speed. Cardiorespiratory fitness and skeletal muscle mitochondrial oxidative capacity contribute to slower walking speeds in older adults with diabetes.
Source: Diabetes
DOI: 10.2337/db23-0827
Authors: Sofhia V. Ramos, Giovanna Distefano, Li-Yung Lui, Peggy M. Cawthon, Philip Kramer, Ian J. Sipula, Fiona M. Bello, Theresa Mau, Michael J. Jurczak, Anthony J. Molina, Erin E. Kershaw, David J. Marcinek, Eric Shankland, Frederico G.S. Toledo, Anne B. Newman, Russell T. Hepple, Stephen B. Kritchevsky, Bret H. Goodpaster, Steven R. Cummings, Paul M. Coen
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: American Diabetes Association, Wake Forest University, University of Pittsburgh, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Advancing Translational Sciences
Awards: G1108988672, G1153142239, G286467573, G2997491251, G3563300324, G4365909528, BAT as a therapeutic for the metabolic and cardiac dysfunction with senescence., G4823677270, G5199590464, G640327682, G889132150, Core Center for Musculoskeletal Biology and Medicine, Study of Muscle, Mobility and Aging: SOMMA2, G94668252
OpenAlex ID: W4393319138