Work

Programmable hyperspectral coherent anti-Stokes Raman scattering microscopy

Year: 2024

Type: article

Abstract: Hyperspectral coherent Raman scattering microscopy provides a significant improvement in acquisition time compared to spontaneous Raman scattering yet still suffers from the time required to sweep through individual wavenumbers. To address this, we present the use of a pulse shaper with a 2D spatial light modulator for phase- and amplitude-based shaping of the Stokes beam to create programmable spectrally tailored excitation envelopes. This enables collection of useful spectral information in a more rapid and efficient manner.

Source: Optics Letters

DOI: 10.1364/ol.521864

Authors: Janet E. Sorrells, Lingxiao Yang, Rishyashring R. Iyer, Eric J. Chaney, Carlos A. Renteria, Stephen A. Boppart

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering