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Supplementary Figure 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Year: 2024

Type: supplementary-materials

Abstract: QC6352 does not cause a biologically significant increase in cell death or apoptosis in WiT49 or HEK293 cells. The percent difference in cell death was statistically significant in HEK293 cells, but the absolute difference was less than 1%. ***paired two-tailed t-test p value <0.001; ns=non-significant.

DOI: 10.1158/1535-7163.25523318

Authors: Prahalathan Pichavaram, Carolyn M. Jablonowski, Jie Fang, Andrew M. Fleming, Hyea Jin Gil, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Christopher L. Morton, Gerard P. Zambetti, Andrew M. Davidoff, Jun Yang, Andrew J. Murphy

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4393438524

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