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Supplementary Figure 13 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Year: 2024

Type: supplementary-materials

Abstract: Knockdown of KDM4A alters QC6352 sensitivity. (A) The PrestoBlue assay demonstrated that siRNA-mediated knockdown of KDM4A and C was associated with resistance to QC6352 when compared to parental cells and empty vector control in WiT49. (B) The PrestoBlue assay demonstrated that siRNA-mediated knockdown of KDM4A was associated with resistance to QC6352 when compared to parental cells and empty vector control in HEK293. (C)IC50 values for WiT49 and HEK293 with siKDM4A-C and NTC siRNA.

DOI: 10.1158/1535-7163.25523336

Authors: Prahalathan Pichavaram, Carolyn M. Jablonowski, Jie Fang, Andrew M. Fleming, Hyea Jin Gil, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Christopher L. Morton, Gerard P. Zambetti, Andrew M. Davidoff, Jun Yang, Andrew J. Murphy

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4393438641

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