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Aggregated variant data from whole-genome sequenced tinnitus patients (TIGER)

Year: 2022
Type: dataset
Abstract: Aggregated variant data obtained from tinnitus patients from Sweden. Uploaded datasets are storage in annotated csv files. Annotation was performed using VEP (v106), including population frequencies for each variant from gnomAD, non-finnish Europeans from gnomAD, and swedish population from SweGen project. Pathogenicity scores from CADD are also annotated for each variant. Variants from genes found to be enriched in a gene burden analysis can be found in this aggregated dataset. agg.tiger.csv - TIGER cohort is composed by 97 swedish whole-genome sequenced constant tinnitus patients. agg.jaguar.csv - JAGUAR cohort is composed by 147 swedish whole-exome sequenced tinnitus patients . agg.sevtin.csv - SEVTIN cohort is a subcohort from TIGER, with 34 WGS patients seggregating severe tinnitus phenotype. agg.controls.csv - Controls is a swedish population cohort composed by 151 whole-exome sequenced swedish individuals.
DOI: 10.5281/zenodo.7304955
Authors: Gallego-Martinez, Alvaro, Escalera-Balsera, Alba, Trpchevska, Natalia, Robles-Bolivar, Paula, Roman-Naranjo, Pablo, Frejo, Lidia, Perez-Carpena, Patricia, Bulla, Jan, Gallus, Silvano, Canlon, Barbara, Cederroth, Christopher R, Lopez-Escamez, Jose Antonio
Institutions: Universidad de Granada, Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, Karolinska Institutet, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario Virgen de las Nieves, University of Bergen, Mario Negri Institute for Pharmacological Research
Language: English
Subfield: Sensory Systems
Open Access status: green
OpenAlex ID: W4393810897
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