Work

Rational Modification of Human Gut Microbial Metabolites by Dietary Resistant Starch in Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Feasibility Study

Year: 2023

Type: dataset

Abstract: We conducted a prospective longitudinal feasibility study in patients undergoing allo-HCT for hematological malignancies to test the hypothesis that defined and consistent administration of resistant starch will rationally modify intestinal microbiota dependent metabolites, particularly the short chain fatty acids (SCFA), such as butyrate. Ten adults undergoing human leukocyte antigen-matched, related-donor myeloablative allo-HCT were enrolled and received resistant potato starch (RPS) daily from day -7 to day 100 after allo-HCT.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.7807173

Authors: Riwes, Mary, Golob, Jonathan L, Magenau, John, Lyssiotis, Costas, Shan, Mengrou, Dick, Gregory, Braun, Thomas, Schmidt, Tom, Pawarode, Attaphol, Anand, Sarah, Ghosh, Monalisa, Maciejewski, John, King, Darren, Choi, Sung, Yanik, Gregory, Geer, Marcus, Tewari, Muneesh, Reddy, Pavan

Institution: University of Michigan

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4393492745

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Related to: 10