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Supplementary Figure 8 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Year: 2024
Type: supplementary-materials
Abstract: QC6352 treatment (25nM x 72 hours) reduces expression of KDM4A in the nucleolus in WiT49 and HEK293. (A) Co-localization of KDM4A (red) and RNA polymerase I (green) is demonstrated in the nucleoli of WiT49 cells. QC6352 treatment caused (B) reduced expression of KDM4A in WiT49 cells (p<0.0001) and (C-D) reduced expression of KDM4A (p<0.0001) and RNA polymerase I (p=0.0370) in HEK293 cells.
DOI: 10.1158/1535-7163.25523303.v1
Authors: Prahalathan Pichavaram, Carolyn M. Jablonowski, Jie Fang, Andrew M. Fleming, Hyea Jin Gil, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Christopher L. Morton, Gerard P. Zambetti, Andrew M. Davidoff, Jun Yang, Andrew J. Murphy
Language: English
Open Access status: gold
OpenAlex ID: W4393499460
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