Supplementary Figure 6 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Year: 2024
Type: supplementary-materials
Abstract: PRISM gene set analysis. (A) PRISM multiplexed cell line profiling RNA expression and compound sensitivity correlation analysis from 931 cancer cell lines was utilized to determine genes with basal RNA expression that correlated with QC6352 sensitivity. Analysis of the top 100 genes with basal expression levels associated with QC6352 sensitivity using the Enrichr database demonstrated that 9 of the top 10 pathways identified on gene set analysis were associated with the ribosome. (B) Tabular view of the top 10 gene sets. (C) Individual ribosomal protein genes comprising the gene sets from A and B that were among the top 100 genes in the PRISM analysis.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4393500067