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Supplementary Figure 5 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Year: 2024

Type: supplementary-materials

Abstract: Gene set enrichment analysis demonstrated significant downregulation of the REACTOME_EUKARYOTIC_TRANSLATION_INITIATION and REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA pathways in QC6352-treated WiT49 cells and the REACTOME_EUKARYOTIC_TRANSLATION_INITIATION pathway in HEK293 cells.

DOI: 10.1158/1535-7163.25523312

Authors: Prahalathan Pichavaram, Carolyn M. Jablonowski, Jie Fang, Andrew M. Fleming, Hyea Jin Gil, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Christopher L. Morton, Gerard P. Zambetti, Andrew M. Davidoff, Jun Yang, Andrew J. Murphy

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4393500592

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