Work

SCLC brain metastasis

Year: 2021

Type: dataset

Abstract: Brain metastasis is a major cause of morbidity and mortality in cancer patients. Here we investigated mechanisms allowing small-cell lung cancer (SCLC) cells to grow in the brain. We show that SCLC cells undergo a cell state transition towards neuronal differentiation during tumor progression and metastasis, and that this neuronal mimicry is critical for SCLC growth in the brain.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.5068365

Authors: Fangfei Qu, Siqi Cao, Chioma Madubata, Drainas, Alexandros P.

Institution: Stanford University

Language: English

Topic: Brain Metastases and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4393567421

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Related to: 10