Work

Inferring B cell phylogenies from paired heavy and light chain BCR sequences with Dowser

Year: 2023

Type: dataset

Abstract: In our publication, we created simulations of paired heavy and light chain BCR sequences. Uploaded here is all the data needed to rerun the simulations, as well as the output of the simulations we ran. The output of BCR phylo included here are the lineage trees, unpickled and put into one file (true_trees.tsv), and the fasta files ('starting_fastas' folder). The naive BCR sequences we used as a starting point are found in the 'naive_data' folder. The post-simulation data for all 20 iterations (combined heavy and light chain data through both simulation frameworks) can be found in the 'simulation_data' folder.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.8338673

Authors: Jensen, Cole G., Sumner, Jacob A., Kleinstein, Steven H., Hoehn, Kenneth B.

Institution: Yale University

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4393535902

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Related to: 10