Proccessed Data for the Pipelines of the Project "Multiomics and quantitative modelling disentangle diet, host, and microbiota contributions to the host metabolome"
Year: 2022
Type: dataset
Abstract: Proccessed Data for the Pipelines of the Project "Multiomics and quantitative modelling disentangle diet, host, and microbiota contributions to the host metabolome" Contents: Folder /metabolomics/ contains processed metabolomics data from the project: /metabolomics/metabolites_allions_combined_norm_intensity.csv - file containing normalized intensities of ions detected across tissues with six measurement methods. /metabolomics/metabolites_allions_combined_formulas_with_metabolite_filters_spatial100clusters_with_mean.csv - file containing metabolite attribution to spatial clusters and mean intensity values across tissues and conditions. Folder /output/ contains example output of the pipelines: /output/model_results_SMOOTH_raw_2LIcoefHost1LIcoefbact_allions.csv - file containing estimated model parameters (intestinal flux and metabolic flux values) for the forward problem for metabolomics measurements in the GIT. /output/model_results_SMOOTH_normbyabsmax_reciprocal_problem_allions.csv - file containing estimated model parameters for the reverse problem (metabolite intensities) for the parameters estimated with the forward problem. /output/model_results_SMOOTH_normbyabsmax_2LIcoefHost1LIcoefbact_allions.csv - file containing estimated model parameters (intestinal flux and metabolic flux values) for the forward problem for metabolomics measurements in the GIT, normalized by absolute maximum value. /output/model_results_SMOOTH_normbyabsmax_ONLYMETCOEF_2LIcoefHost1LIcoefbact_allions.csv - file containing estimated model parameters (only metabolic flux values) for the forward problem for metabolomics measurements in the GIT, normalized by absolute maximum value. /output/table_hierarchical_clustering_groups.csv - file containing attribution of the annotated metabolites to groups according to hierarchical clustering of the normalized model parameters. /output/cgo_clustergrams_of_model_coefficients.mat - matlab object containing clustergram of the normalized model parameters and manually derived sub-clustergrams corresponding to different largest parameter values.
Authors: Zimmermann-Kogadeeva, Maria, Bencivenga-Barry, Natasha A, Zimmermann, Michael, Bork, Peer, Goodman, Andrew L.
Institutions: European Molecular Biology Laboratory, Yale University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4393821869