Dataset related to the article "Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis"
Year: 2020
Type: dataset
Abstract: This record contains raw data related to the article "Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis" ABSTRACT The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with noncarriers. PCSK9 expression was higher in the aortic valves of patients CAVS compared with control patients. In human valve interstitials cells submitted to a pro-osteogenic medium, PCSK9 levels increased and a PCSK9 neutralizing antibody significantly reduced calcium accumulation.
Source: Figshare
Authors: Perrot Nicolas, Valerio, Vincenza, Moschetta, Donato, Boekholdt, Matthijs, Dina, Christian, Yu Chen, Hao, Abner, Erik, Martinsson, Andreas, Manikpurage, Hasanga, Rigade, Sidwell, Capoulade, Romain, Mass, Elvira, Clavel, Marie-Annick, Thierry, Le Tourneau, Messika-Zeitonun, David, Wareham, Nicholas, Engert, James, Polvani, Gianluca, Pibarot, Philippe, Esko, Tonu, Smith, Gustav, Mathieu, Patrick, Thanassoulis, George, Schott, Jean-Jacques, Bossé, Yohan, Camera, Marina, Thériault, Sébastien, Poggio, Paolo, Arsenault, Benoit
Institutions: Institut universitaire de cardiologie et de pneumologie de Québec, Centro Cardiologico Monzino, Amsterdam UMC Location University of Amsterdam, Centre National de la Recherche Scientifique, Inserm, Centre Hospitalier Universitaire de Nantes, Institut du Thorax, McGill University Health Centre, Research Institute of the McGill University Health Centre, McGill University, University of Tartu, Lund University, Skåne University Hospital, University of Bonn, Assistance Publique – Hôpitaux de Paris, Hôpital Bichat-Claude-Bernard, University of Cambridge
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4393633398