Dataset related to article "CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential."
Year: 2020
Type: dataset
Abstract: In mice, the ability of naive T (TN) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8+ TN cells, defined by the absence or presence of the chemokine receptor CXCR3. The more abundant CXCR3+ TN cell subset displayed an effector-like transcriptional profile and expressed TCRs with physicochemical characteristics indicative of enhanced interactions with peptide-HLA class I Ags. Moreover, CXCR3+ TN cells frequently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiated readily into Ag-specific effector cells in vitro. Comparative analyses further revealed that human CXCR3+ TN cells were transcriptionally equivalent to murine CXCR3+ TN cells, which expressed high levels of CD5. These findings provide support for the notion that effector differentiation is shaped by heterogeneity in the preimmune repertoire of human CD8+ T cells.
Source: Figshare
Authors: G, De Simone, Mazza EMC, Cassotta A, Davydov AN, Kuka M, Zanon V, F, De Paoli, Scamardella E, Metsger M, A, Roberto, Pilipow K, FS, Colombo, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, DA, Price, Singh SP, Farber JM, V, Serra, Cucca F, Ferrari F, Orrù V, Fiorillo E, Iannacone M5,, Chudakov DM, Sallusto F, Lugli E
Institutions: IRCCS Humanitas Research Hospital, Institute for Research in Biomedicine, Università della Svizzera italiana, Central European Institute of Technology, Vita-Salute San Raffaele University, IRCCS San Raffaele Roma, University of Modena and Reggio Emilia, National Cancer Institute, Center for Cancer Research, Cardiff University, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Institute of Genetic and Biomedical Research, National Research Council, IFOM
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4393681832