Multi-Omic Approach Associates Blood Methylome with Bronchodilator Drug Response in Pediatric Asthma: Summary statistics
Year: 2021
Type: dataset
Abstract: We conducted an epigenome-wide association study of bronchodilator drug response (BDR) in a discovery and validation design. The discovery phase was focused on 221 African American children with asthma. The association between DNA methylation and BDR was conducted using the limma package correcting for age, sex, ancestry, and tissue heterogeneity. Summary statistics include the output from toptable limma function and CpG annotation (based on Illumina EPIC Manifest file v 1.0 B4) organized in the following columns: Probe: Probe ID Chr: chromosome Pos: genomic position based on GRCh37/hg19 Gene: Gene annotation based on Illumina EPIC Manifest file v 1.0 B4 logFC: estimate of the log2-fold-change corresponding to the effect or contrast SE: standard error AveExpr: average log2-expression for the probe over all arrays and channels t: moderated t-statistic P.value: raw p-value FDR: adjusted p-value by false discovery rate B: log-odds that the gene is differentially expressed Problem: Flagged potentially problematic probes
Authors: Perez-Garcia, Javier, Herrera-Luis, Esther, Li, Annie, Mak, Angel CY, Huntsman, Scott, Oh, Sam S, Elhawary, Jennifer R, Eng, Celeste, Beckman, Kenneth B, Donglei Hu, Lenoir, Michael A, Rodriguez-Santana, Jose, Zaitlen, Noah, Villar, Jesús, Borrel, Luisa N, Burchard, Esteban G, Pino-Yanes, Maria
Institutions: Universidad de La Laguna, University of California, San Francisco, University of Minnesota, Centro de Neumologia Pediatrica, University of California, Los Angeles, Instituto de Salud Carlos III, Hospital Universitario de Gran Canaria Doctor Negrín, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, City University of New York, Centro de Investigación Biomédica en Red
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4393755429