Work

FIGURE 2 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate

Year: 2024

Type: other

Abstract: VCAN is associated with T-cell localization. A, Matrix index from Pearce and colleagues (14). Arrows indicate upregulation or downregulation at gene (G) or protein (P) level. B, Level of gene expression of top five upregulated molecules in 100 samples from TCGA dataset. C, scRNA-seq expression of the five genes indicating which cell types express the genes and the percentage of those cells that are positive. Data obtained from Wu and colleagues (25). D, IHC completed on consecutive TMA cores for COL11A1, COMP, CTSB, FN1, and VCAN. Spearman rank correlation of the expression of proteins from IHC analysis of eight TMA cores. **, P < 0.01 (N = 8). E, Comparison of dual RNAscope for CTSB (green) and VCAN (red) with IHC staining for CD8.

DOI: 10.1158/2767-9764.25534457

Authors: Priyanka Hirani, Jacqueline McDermott, Vinothini Rajeeve, Pedro R. Cutillas, J. Louise Jones, Daniel J. Pennington, Thomas N. Wight, Salvatore Santamaria, Kimberly M. Alonge, Oliver M.T. Pearce

Language: English

Topic: Proteoglycans and glycosaminoglycans research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4393870845

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Related to: 10