Year: 2024
Type: article
Abstract: Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type-specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.
Source: Science
Institutions: German Center for Neurodegenerative Diseases (DZNE) Dresden, Salk Institute for Biological Studies, Kura Oncology (United States), German Center for Diabetes Research, University Hospital Carl Gustav Carus, Paul Langerhans Institute Dresden, DRESDEN-concept Genome Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Institute of Science and Technology Austria, Friedrich-Alexander-Universität Erlangen-Nürnberg
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Elucidating the effects of ageing on the nucleoporin-directed neural cell type-specific nuclear architecture and gene regulation, DRESDENconcept Genome Center, The role of nuclear architectural RNAs in the long-term maintenance of the neural epigenome, Zentrale Koordinationseinheit des Next Generation Sequencing Kompetenznetzwerks
OpenAlex ID: W4393951843