Work

The helminth‐derived peptide, FhHDM‐1, reverses the trained phenotype of NOD bone‐marrow‐derived macrophages and regulates proinflammatory responses

Year: 2024

Type: article

Abstract: We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.

Source: European Journal of Immunology

DOI: 10.1002/eji.202350643

Authors: Susel Loli Quinteros, Nathaniel W. Snyder, Adam Chatoff, Fiona Ryan, Bronwyn O'Brien, Sheila Donnelly

Institutions: University of Technology Sydney, Temple University

Language: English

Topic: Immune responses and vaccinations

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,330